Anti-Desmin Mouse, Unlabeled, Clone: RD301, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 550626

Catalog No. BDB550626

Description

Intermediate filaments (IF) are a subset of cytoskeletal proteins which function to give overall structural integrity to the plasma membrane as well as organize cells into specific tissues. IF proteins can be divided into six major types based upon the similarity in sequence. Desmin belongs to the type III category of IF proteins which are predominantly expressed in muscle cells including cardiac, skeletal and smooth muscle. Furthermore, the expression of desmin is regulated in a stage and tissue-specific manner, since it is induced during terminal differentiation of skeletal muscle cells. In skeletal cardiac muscle cells, desmin is localized in the Z-disk region and at the intercalated disk and acts to stabilize sarcomeres in stimulated muscle. Desmin migrates in SDS/PAGE as a 53 kDa protein.

Specifications

• Antigen: Anti-Desmin
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Purified desmin from chicken gizzard
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Chicken, Human, Mouse, Rat
• Isotype: IgG2b

• Applications: Western Blot
• Clone: RD301
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.