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AP50 Mouse, Unlabeled, Clone: 31, BD

Catalog No. BDB611350 Shop All BD Biosciences Products
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50 μg
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BDB611351 150 μg
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Catalog No. BDB611350 Supplier BD Biosciences Supplier No. 611350
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Description

Mouse Monoclonal Antibody

Sorting of integral membrane proteins is mediated vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (γ, α, δ, ε, and β1, β2, β3, β4 respectively) that are noncovalently linked to one medium chain (μ1, μ2, μ3, μ4 respectively) and one small chain ( σ1, σ2, σ3, σ4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2, μ2 (AP50) interacts with integral membrane proteins via binding to tyrosine-based signals with the canonical motif YXXφ. In addition, AP50/μ2 is required for both the assembly and the proton transport activity of vacuolar (H+)-ATPases in clathrin coated vesicles. Thus, AP50/μ2 may be involved in targeting integral membrane proteins that are sorted based on tyrosine-based signals and involved in assembly of functional ion channels associated with clathrin coated vesicles.

Host Species: Mouse
Clone: 31
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse AP50/μ2 aa. 110-230
Formula Weight [Chemical]: 50kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen AP50
Applications Western Blot
Classification Monoclonal
Clone 31
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse AP50/μ2 aa. 110-230
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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