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APC10 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520950

Catalog No. PIPA520950


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Description

Description

A suggested positive control is mouse heart tissue lysate. PA5-20950 can be used with blocking peptide PEP-1064.

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. It has been suggested that APC10 plays a role to regulate the binding of specific substrates to the APC/C complex, similar to that of coactivators.
Specifications

Specifications

APC10
Polyclonal
Unconjugated
ANAPC10
Liquid
ANAPC10
A 16 amino acid peptide near the center of human APC10.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9UM13, Q8K2H6
APC10, DOC1; anaphase-promoting complex subunit 10; cyclosome subunit 10
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
10393, 361389, 68999
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