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APAF1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112512

Catalog No. 01-674-172


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Description

Description

A suggested positive control for this product is HeLa whole cell lysate.

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Cell death signals are transduced by death domain containing adaptor molecules and members of the caspase family of proteases. The human and mouse homologues to C. elegans death receptor 4 (CED-4) have recently been isolated and named Apaf-1. Apaf-1 binds to cytochrome C and caspase-9 (also known as Apaf-2 and Apaf-3, respectively), leading to activation of caspase-9. Activated caspase-9 activates caspase-3, leading to the proteolytic cleavage of a number of different proteins involved in the apoptotic cascade. Apaf-1 is ubiquitously expressed in human tissues and has also been shown to interact with caspase-4 and caspase-8.
Specifications

Specifications

APAF1
Polyclonal
PBS with 0.02% sodium azide
O14727, O88879, Q9EPV5
CED4
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
11783, 317, 78963
Western Blot
Unconjugated
APAF1
Liquid
APAF1
Synthetic peptide corresponding to residues 12-28 of the human Apaf-1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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