APOC4, Mouse, Clone: 2C12, Abnova
Mouse monoclonal antibody raised against a full-length recombinant APP.
Manufacturer: Abnova Corporation H00000351M01
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeqSequence: EVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREKWYKEVHSGQARWLML
|AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2|
|Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|ELISA,Immunoprecipitation,Sandwich ELISA,Western Blot|
|amyloid beta (A4) precursor protein|
|In 1X PBS, pH 7.4|
|APOC4 (AAH20723, 27 a.a. ∽128 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26kDa.|
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