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APP-BP1 Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611864

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Catalog No. BDB611864

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.



Amyloid precursor protein (APP) gene encodes multiple APPs ranging from 695 to 770 amino acids. These proteins are processed into β-Amyloid peptides (39-43 amino acids), which form abnormal plaques in the cerebral cortex and blood vessel walls during Alzheimer's disease. The transmembrane form of APP is a putative cell surface receptor that possesses neurite-promoting activity, co-localizes with the plaques found in Alzheimer's disease, and is involved in synaptic vesicle recycling. APP binding protein 1 (APP-BP1) interacts with the C-terminus of APP, and is a relative of the ubiquitin-activating enzymes (E1). The structure of APP-BP1 includes a human Uba3 binding site (UBS) at amino acids 443 to 479. This site may be important for APP-BP1 regulation of the cell cycle through interactions with ubiquitinylation-related pathways. Transfection of APP-BP1 in cells with a ts41 mutation suppresses the abnormal S-phases observed in these cells in a hUba3- and hUbc12-dependent manner. In addition, APP-BP1 has been implicated in ubiquitinylation-dependent apoptosis in neurons. Thus, APP-BP1 may be a multi-functional APP-binding protein that regulates cell cycle dynamics.

Host Species: Mouse
Clone: 20
Isotype: IgG2a
Species Reactivity [for Features Main]: Mouse
Immunogen: Human APP-BP1 aa. 348-464

Immunofluorescence, Western Blotting



Canine, Human, Murine, Rat
Western Blot
Affinity Purified
Human APP-BP1 aa. 348-464
Cell Biology
Product Certifications


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