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  6. APP-BP1 Mouse, Unlabeled, Clone: 20, BD

APP-BP1 Mouse, Unlabeled, Clone: 20, BD

Catalog No. BDB611864 Shop All BD Biosciences Products
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BDB611865 150 μg
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Catalog No. BDB611864 Supplier BD Biosciences Supplier No. 611864

Description

Mouse Monoclonal Antibody

Amyloid precursor protein (APP) gene encodes multiple APPs ranging from 695 to 770 amino acids. These proteins are processed into β-Amyloid peptides (39-43 amino acids), which form abnormal plaques in the cerebral cortex and blood vessel walls during Alzheimer's disease. The transmembrane form of APP is a putative cell surface receptor that possesses neurite-promoting activity, co-localizes with the plaques found in Alzheimer's disease, and is involved in synaptic vesicle recycling. APP binding protein 1 (APP-BP1) interacts with the C-terminus of APP, and is a relative of the ubiquitin-activating enzymes (E1). The structure of APP-BP1 includes a human Uba3 binding site (UBS) at amino acids 443 to 479. This site may be important for APP-BP1 regulation of the cell cycle through interactions with ubiquitinylation-related pathways. Transfection of APP-BP1 in cells with a ts41 mutation suppresses the abnormal S-phases observed in these cells in a hUba3- and hUbc12-dependent manner. In addition, APP-BP1 has been implicated in ubiquitinylation-dependent apoptosis in neurons. Thus, APP-BP1 may be a multi-functional APP-binding protein that regulates cell cycle dynamics.

Host Species: Mouse
Clone: 20
Isotype: IgG2a
Species Reactivity [for Features Main]: Mouse
Immunogen: Human APP-BP1 aa. 348-464

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen APP-BP1
Applications Western Blot
Classification Monoclonal
Clone 20
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Human APP-BP1 aa. 348-464
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Human, Mouse, Rat
Isotype IgG2a
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For Research Use Only.

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