APP-BP1 Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 611865

Catalog No. BDB611865

Description

Amyloid precursor protein (APP) gene encodes multiple APPs ranging from 695 to 770 amino acids. These proteins are processed into β-Amyloid peptides (39-43 amino acids), which form abnormal plaques in the cerebral cortex and blood vessel walls during Alzheimer's disease. The transmembrane form of APP is a putative cell surface receptor that possesses neurite-promoting activity, co-localizes with the plaques found in Alzheimer's disease, and is involved in synaptic vesicle recycling. APP binding protein 1 (APP-BP1) interacts with the C-terminus of APP, and is a relative of the ubiquitin-activating enzymes (E1). The structure of APP-BP1 includes a human Uba3 binding site (UBS) at amino acids 443 to 479. This site may be important for APP-BP1 regulation of the cell cycle through interactions with ubiquitinylation-related pathways. Transfection of APP-BP1 in cells with a ts41 mutation suppresses the abnormal S-phases observed in these cells in a hUba3- and hUbc12-dependent manner. In addition, APP-BP1 has been implicated in ubiquitinylation-dependent apoptosis in neurons. Thus, APP-BP1 may be a multi-functional APP-binding protein that regulates cell cycle dynamics.

Host Species: Mouse
Clone: 20
Isotype: IgG2a
Species Reactivity [for Features Main]: Mouse
Immunogen: Human APP-BP1 aa. 348-464

Immunofluorescence, Western Blotting

Specifications

• Antigen: APP-BP1
• Classification: Monoclonal
• Concentration: 250μg/mL
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Isotype: IgG2a

• Applications: Western Blot
• Clone: 20
• Conjugate: Unconjugated
• Immunogen: Human APP-BP1 aa. 348-464
• Quantity: 150 μg
• Research Discipline: Cell Biology
• Target Species: Canine, Human, Mouse, Rat

For Research Use Only.