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MilliporeSigma™ anti-Aprataxin, Polyclonal

Catalog No. ABE1944MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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ABE1944MI 100 μL Unconjugated
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Catalog No. ABE1944MI Supplier MilliporeSigma™ Supplier No. ABE1944
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Description

Rabbit Polyclonal Antibody

Specifically detects Aprataxin Clone: in Human samples, and it is validated for Immunoprecipitation, Western Blotting

Aprataxin (UniProt Q7Z2E3; also known as FHA-HIT, Forkhead-associated domain histidine triad-like protein) is encoded by the APTX (also known as AOA, AOA1, AXA1, EAOH, EOAHA) gene (Gene ID 54840) in human. Aprataxin contains an N-terminal forkhead-associated (FHA; a.a. 38-87) domain akin to that found in the DNA end damage repair factor polynucleotide kinase phosphatase (PNKP), followed by a histidine triad (HIT; a.a. 182-287) domain found in nucleoside hydrolases and transferases, and a C-terminal C2H2 type Zinc finger domain. Aprataxin exhibits both DNA- and RNA-binding activity and plays a role in reversing toxic 5'-adenylated (5'-AMP) DNA lesions generated by DNA ligases when encountering nicked DNA structures with abnormal DNA termini. Aprataxin functions as a DNA ligase proofreader to directly reverse damaged 5'-adenylated termini of DNA strand breaks that have been subjected to DNA damage-induced abortive processing by DNA ligases. Ataxia with oculomotor apraxia type 1 (AOA1) is an autosomal recessive neurological syndrome caused by an impairment in DNA repair as a result of APTX gene mutations. The related type 2 disorder AOA2 is caused by a Senataxin-deficiency due to SETX gene mutations.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Aprataxin
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation Rabbit polyclonal antibody in serum with 0.05% sodium azide.
Gene Accession No. Q7Z2E3
Gene Symbols APTX, AOA, AOA1, AXA1, EAOH, EOAHA
Host Species Rabbit
Immunogen Recombinant full-length human aprataxin.
Purification Method Unpurified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Epigenetics, Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_001182177
Test Specificity Expected to react with all 13 human aprataxin spliced isoforms reported by UniProt (Q7Z2E3-1 through Q7Z2E3-13).
Target Species Human
Content And Storage −20°C for one year
Form Serum
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For Research Use Only

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