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MilliporeSigma™ anti-ARSA, Polyclonal

Catalog No. AP113850UG Shop All MilliporeSigma Products
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Quantity:
50 μg
Conjugate:
Unconjugated
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AP113850UG 50 μg Unconjugated
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Description

Mouse Polyclonal Antibody

Specifically detects ARSA Clone: in Human samples, and it is validated for Immunohistochemistry (Paraffin)

ARSA hydrolyzes cerebroside sulfate. Defects in ARSA are known to cause metachromatic leukodystrophy (MLD). MLD is a disease due to a lysosomal storage defect. It is characterized by intralysosomal storage of cerebroside-3-sulfate in neural and non-neural tissues, with a diffuse loss of myelin in the central nervous system. Progressive demyelination causes a variety of neurological symptoms, including gait disturbances, ataxias, optical atrophy, dementia, seizures, and spastic tetraparesis. Three forms of the disease can be distinguished according to the age at onset: late-infantile, juvenile and adult.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARSA
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Unconjugated
Formulation In PBS, pH 7.2.
Host Species Mouse
Immunogen Full length human ARSA (aa 1-507)
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽55kDa ARSA protein in human lymph node tissue.
Target Species Human
Content And Storage −20°C
Form Purified
Isotype IgG
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