MilliporeSigma™ anti-ARSA, Polyclonal

Mouse Polyclonal Antibody

Supplier:  MilliporeSigma™ AP113850UG

Catalog No. AP113850UG

Description

Specifically detects ARSA Clone: in Human samples, and it is validated for Immunohistochemistry (Paraffin)

ARSA hydrolyzes cerebroside sulfate. Defects in ARSA are known to cause metachromatic leukodystrophy (MLD). MLD is a disease due to a lysosomal storage defect. It is characterized by intralysosomal storage of cerebroside-3-sulfate in neural and non-neural tissues, with a diffuse loss of myelin in the central nervous system. Progressive demyelination causes a variety of neurological symptoms, including gait disturbances, ataxias, optical atrophy, dementia, seizures, and spastic tetraparesis. Three forms of the disease can be distinguished according to the age at onset: late-infantile, juvenile and adult.

Specifications

• Antigen: ARSA
• Classification: Polyclonal
• Formulation: In PBS, pH 7.2.
• Immunogen: Full length human ARSA (aa 1-507)
• Regulatory Status: RUO
• Test Specificity: Recognizes the ∽55kDa ARSA protein in human lymph node tissue.
• Content And Storage: −20°C
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Mouse
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only