MilliporeSigma™ anti-Arylsulfatase B Clone: 10G6.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABC975

Catalog No. MABC975MI

Description

Specifically detects Arylsulfatase B Clone: 10G6.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Arylsulfatase B (EC 3.1.6.12; UniProt P15848; also known as ASB, G4S, N-acetylgalactosamine-4-sulfatase) is encoded by the ARSB (also known as MPS6) gene (Gene ID 411) in human. Arylsulfatases consistute a group of enzymes found in the lysosomes of the liver, pancreas, and kidneys. Arylsulfatase B mediates the breakdown of two glycosaminoglycans (GAGs), dermatan sulfate and chondroitin sulfate. Arylsulfatase B-catalyzed removal of sulfate groups from chondroitin-4-sulfate (C4S) leads to the degradation of C4S. Cellular arylsulfatase B expression is also reported to be found in non-lysosomal compartments, including the plasma membrane. Arylsulfatase B is initially produced with a signal peptide sequence (a.a. 1-36), the removal of which yields the mature enzyme. Arylsulfatase B-deficiency due to ARSB mutations results in an accumulation of GAGs in lysosomes, which in turn can lead to Maroteaux-Lamy syndrome or mucopolysaccharidosis VI (MPS6).

Specifications

• Antigen: Arylsulfatase B
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Accession No.: P15848
• Host Species: Mouse
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Expected to react with both spliced isoforms of human Arylsulfatase B reported by UniProt (P15848-1 and P15848-2).
• Content And Storage: -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
• Isotype: IgG2a κ

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 10G6.1
• Formulation: Mouse monoclonal IgG2aκ antibody in tissue culture supernatant without preservatives.
• Gene Symbols: ARSB, MPS6
• Immunogen: GST-tagged recombinant human Arylsulfatase B N-terminal fragment.
• Quantity: 100 μL
• Research Discipline: Apoptosis, Cancer
• Gene ID (Entrez): NP_000037
• Target Species: Human
• Form: Supernatant

For Research Use Only