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MilliporeSigma™ anti-Arylsulfatase B Clone: 10G6.1,

Catalog No. MABC975MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABC975MI 100 μL Unconjugated
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Catalog No. MABC975MI Supplier MilliporeSigma™ Supplier No. MABC975
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Description

Mouse Monoclonal Antibody

Specifically detects Arylsulfatase B Clone: 10G6.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Arylsulfatase B (EC 3.1.6.12; UniProt P15848; also known as ASB, G4S, N-acetylgalactosamine-4-sulfatase) is encoded by the ARSB (also known as MPS6) gene (Gene ID 411) in human. Arylsulfatases consistute a group of enzymes found in the lysosomes of the liver, pancreas, and kidneys. Arylsulfatase B mediates the breakdown of two glycosaminoglycans (GAGs), dermatan sulfate and chondroitin sulfate. Arylsulfatase B-catalyzed removal of sulfate groups from chondroitin-4-sulfate (C4S) leads to the degradation of C4S. Cellular arylsulfatase B expression is also reported to be found in non-lysosomal compartments, including the plasma membrane. Arylsulfatase B is initially produced with a signal peptide sequence (a.a. 1-36), the removal of which yields the mature enzyme. Arylsulfatase B-deficiency due to ARSB mutations results in an accumulation of GAGs in lysosomes, which in turn can lead to Maroteaux-Lamy syndrome or mucopolysaccharidosis VI (MPS6).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Arylsulfatase B
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 10G6.1
Conjugate Unconjugated
Formulation Mouse monoclonal IgG2aκ antibody in tissue culture supernatant without preservatives.
Gene Accession No. P15848
Gene Symbols ARSB, MPS6
Host Species Mouse
Immunogen GST-tagged recombinant human Arylsulfatase B N-terminal fragment.
Purification Method Unpurified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Apoptosis, Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_000037
Test Specificity Expected to react with both spliced isoforms of human Arylsulfatase B reported by UniProt (P15848-1 and P15848-2).
Target Species Human
Content And Storage -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Form Supernatant
Isotype IgG2a κ
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For Research Use Only

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