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MilliporeSigma™ anti-Arylsulfatase B Clone: 10G6.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABC975

Catalog No. MABC975MI


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Description

Description

Specifically detects Arylsulfatase B Clone: 10G6.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Arylsulfatase B (EC 3.1.6.12; UniProt P15848; also known as ASB, G4S, N-acetylgalactosamine-4-sulfatase) is encoded by the ARSB (also known as MPS6) gene (Gene ID 411) in human. Arylsulfatases consistute a group of enzymes found in the lysosomes of the liver, pancreas, and kidneys. Arylsulfatase B mediates the breakdown of two glycosaminoglycans (GAGs), dermatan sulfate and chondroitin sulfate. Arylsulfatase B-catalyzed removal of sulfate groups from chondroitin-4-sulfate (C4S) leads to the degradation of C4S. Cellular arylsulfatase B expression is also reported to be found in non-lysosomal compartments, including the plasma membrane. Arylsulfatase B is initially produced with a signal peptide sequence (a.a. 1-36), the removal of which yields the mature enzyme. Arylsulfatase B-deficiency due to ARSB mutations results in an accumulation of GAGs in lysosomes, which in turn can lead to Maroteaux-Lamy syndrome or mucopolysaccharidosis VI (MPS6).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Arylsulfatase B
Monoclonal
Unconjugated
P15848
Mouse
Unpurified
RUO
Primary
Expected to react with both spliced isoforms of human Arylsulfatase B reported by UniProt (P15848-1 and P15848-2).
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
IgG2a κ
Immunohistochemistry (Paraffin), Western Blot
10G6.1
Mouse monoclonal IgG2aκ antibody in tissue culture supernatant without preservatives.
ARSB, MPS6
GST-tagged recombinant human Arylsulfatase B N-terminal fragment.
100 μL
Apoptosis, Cancer
NP_000037
Human
Supernatant
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