ASAH2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520575
A suggested positive control is 293 cell lysate. PA5-20575 can be used with blocking peptide PEP-0695.Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine, kidney, skeletal muscle and heart. Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract.
|A 17 amino acid peptide near the carboxy terminus of the human ASAH2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|Q9NR71, Q9JHE3, Q91XT9|
|BCDase, HNAC1, LCDase, N-CDase, NCDase; N-acylsphingosine amidohydrolase 2; acylsphingosine deacylase 2; mitochondrial ceramidase; neutral ceramidase; neutral/alkaline ceramidase; non-lysosomal ceramidase|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|114104, 54447, 56624|
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