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MilliporeSigma™ anti-ATF-3 Clone: 13A5.1,

Catalog No. MABN124MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABN124MI 100 μL Unconjugated
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Catalog No. MABN124MI Supplier MilliporeSigma™ Supplier No. MABN124
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Description

Human Monoclonal Antibody

Specifically detects ATF-3 Clone: 13A5.1 in Human, Mouse samples, and it is validated for Western Blotting

Cyclic AMP-dependent transcription factor ATF-3 (UniProt P18847; also known as Activating transcription factor 3, cAMP-dependent transcription factor ATF-3) is encoded by the ATF3 gene (Gene ID 467) in human. ATF-3 belongs to the ATF/cAMP-responsive element-binding protein family of basic leucine zipper-type transcription factors. ATF-3 is markedly induced and functions as either a transcriptional activator or repressor in response to LPS, cytokines, hormones, DNA damage, and ER stress in various cell types. ATF3 plays key roles in atherosclerosis and hyperlipidemia, and is reported to negatively regulate the differentiation of adipocyte, chondrocyte, and osteoblast. ATF-3 dysfunction is closely related to various inflammatory diseases and cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATF-3
Applications Western Blot
Classification Monoclonal
Clone 13A5.1
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P18847
Gene Symbols ATF3
Host Species Human
Immunogen GST-tagged recombinant human ATF-3 fragment.
Purification Method Protein G purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_001665
Test Specificity Expected to react with spliced isoforms 1 and 5 (UniProt P18847-1 and P18847-5). Reactivity toward spliced isoforms 2, 3, and 4 (UniProt P18847-2 through P18847-4) of human ATF-3 has not been determined.
Target Species Human, Mouse
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG2b κ
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For Research Use Only

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