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ATM, Mouse, Clone: 2C10, Abnova™

Catalog No. 89123139 Shop All Abnova Corporation Products
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89-123-139 100 μg
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Catalog No. 89-123-139 Supplier Abnova Corporation Supplier No. H00000472M05
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Description

Mouse monoclonal antibody raised against a full-length recombinant ATM.

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Sequence: MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVVKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRKLTIFSQ

Specifications

Antigen ATM
Applications ELISA, Immunofluorescence
Classification Monoclonal
Clone 2C10
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against a full-length recombinant ATM.
Formulation PBS with no preservative; pH 7.4
Gene ATM
Gene Accession No. BC007023.1
Gene Alias AT1/ATA/ATC/ATD/ATDC/ATE/DKFZp781A0353/MGC74674/TEL1/TELO1
Gene Symbols ATM
Host Species Mouse
Immunogen ATM (AAH07023.1, 1 a.a. ∼ 138 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 472
Target Species Human
Content And Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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