Invitrogen™ ATP2C1 Monoclonal Antibody (4G12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515592

Catalog No. PIMA515592

Description

MA5-15592 targets ATP2C1 in indirect ELISA, IHC and WB applications and shows reactivity with Human and Non-human primate samples. The MA5-15592 immunogen is purified recombinant fragment of ATP2C1 expressed in E. Coli. MA5-15592 detects ATP2C1 which has a predicted molecular weight of approximately 100kDa.

ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.

Specifications

• Antigen: ATP2C1
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.03% sodium azide
• Gene Accession No.: P98194
• Gene Symbols: Atp2c1
• Immunogen: Purified recombinant fragment of ATP2C1 expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 27032
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 4G12
• Conjugate: Unconjugated
• Gene: Atp2c1
• Gene Alias: 1700121J11Rik; ATP2C1; ATP2C1A; ATPase 2C1; ATPase secretory pathway Ca2+ transporting 1; ATPase, Ca(2+)-sequestering; ATPase, Ca++ transporting, type 2C, member 1; ATPase, Ca++-sequestering; ATP-dependent Ca(2+) pump PMR1; AW061228; BCPM; calcium-transporting ATPase 2C1; calcium-transporting ATPase type 2C member 1; D930003G21Rik; HHD; hSPCA1; HUSSY 28; HUSSY-28; KIAA1347; Pmr1; PMR1L; rat; secretory pathway Ca(2+)-ATPase 1; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA; SPCA1
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Monkey
• Product Type: Antibody
• Isotype: IgG1