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ATR Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1450

Catalog No. PA1450


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Description

Description

PA1-450 detects ATR (Ataxia Telangiectasia Mutated (ATM) and Rad3-related protein) from human cells. PA1-450 has been successfully used in Western blot immunofluoresence and immunoprecipitation procedures. By Western blot, this antibody detects an ~305 kDa protein representing ATR in lysate from UV irradiated K562 cells. PA1-450 antigen is a fusion protein corresponding to amino acid residues 400-460 from human ATR.

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Specifications

Specifications

ATR
Polyclonal
Unconjugated
ATR
Liquid
ATR
Fusion protein containing residues 400-460 of the human ATR protein.
Affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunofluorescence, Immunoprecipitation, Western Blot
4 mg/mL
PBS with 0.05% sodium azide
Q13535
Ataxia Telangiectasia Mutated (ATM) and Rad3-Related Protein
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
545
Documents
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