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Attractin Mouse anti-Human, Unlabeled, Clone: 14, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611530

Catalog No. BDB611530

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Interactions between cell adhesion molecules and extracellular matrix (ECM) components mediate the migration of antigen specific T cells from the bloodstream to inflammatory sites. CD26, a surface marker of these T cells, is identical to dipeptidyl peptidase (DPPIV). Attractin was identified in serum as a soluble 175kDa form of DPPIV, termed DPPT-L. It is a member of the CUB domain familly, which includes the complement proteins C1r/C1s, Uegf, and BMP-1 (procollagen C proteinase), a protein that regulates cell interactions during development.
Although unable to induce cell proliferation on its own, attractin enhances the proliferative response of PBMC in the presence of antigen. Attractin mediates the spreading of monocytes (antigen presenting cells; APCs) which become the focus for T cell clustering and formation of the immunoregulatory unit. Thus, attractin is thought to modulate the interaction between T cells and APCs, thereby enhancing the effectiveness of antigen presentation. In addition, attractin is the human homolog of the mahogany protein, a transmembrane signaling receptor
involved in suppression of the obesity observed in mice with the agouti-lethal-yellow mutation.

Host Species: Mouse
Clone: 14
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Attractin aa. 184-383
Formula Weight [Chemical]: 175kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Attractin
14
Unconjugated
Murine
IgG1
RUO
Primary
Human
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human Attractin aa. 184-383
50μg
Cell Biology
Monoclonal
Documents
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