Learn More
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I), Mouse, Purified MaxPab™ Polyclonal Antibody, Abnova™
Mouse polyclonal antibody raised against a full-length human B4GALT7 protein.
Supplier: Abnova Corporation H00011285B01P
Description
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) linkage found in proteoglycans. Manganese is required as a cofactor. This enzyme differs from the other six beta4GalTs because it lacks the conserved beta4GalT1-beta4GalT6 Cys residues and it is located in cis-Golgi instead of trans-Golgi. Two single-nucleotide mutations were identified from a patient with the progeroid type of Ehlers-Danlos syndrome. [provided by RefSeq
Sequence: MFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARAVRGQGQETSGPPRACPPEPPPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLHDPAWRKRDQKRIAAQKQEQFKVDREGGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFSSpecifications
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) | |
Polyclonal | |
Mouse polyclonal antibody raised against a full-length human B4GALT7 protein. | |
B4GALT7 | |
B4GAL-T7/XGALT-1/XGALT1/XGPT1/beta4Gal-T7 | |
Mouse | |
Affinity Purified | |
RUO | |
11285 | |
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
IgG |
Western Blot | |
Unconjugated | |
PBS with no preservative; pH 7.4 | |
NM_007255.1 | |
B4GALT7 | |
B4GALT7 (NP_009186.1, 1 a.a. ∼ 327 a.a) full-length human protein. | |
50 μg | |
Primary | |
Human | |
Antibody |
Your input is important to us. Please complete this form to provide feedback related to the content on this product.