B56α Mouse, Unlabeled, Clone: 23, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610615
Reversible phosphorylation by protein kinases and phosphatases regulates key signaling pathways in eukaryotic cells. Type 2A protein phosphatases (PP2A) are composed of two regulatory and one catalytic subunit. The active PP2A is a heterotrimer, composed of A, B, and C subunits, each encoded by different genes. B56 is a new gene family that encodes α, β, and γ proteins for the B subunit. The three B56 isoforms are approximately 70% homologous to each other and more divergent within the first 251amino acids. While the α subunit is widely expressed, the γ isoform is most abundant in heart and muscle, and the β subunit is found predominantly in brain tissue. Availability of different B subunits appears to be a key determinant in the protein substrate specificity for PP2A and could influence the subcellular distribution of the holoenzyme.
|Human B56α aa. 1-162|
|Canine, Chicken, Frog, Human, Murine, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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