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BAF60a Mouse, Unlabeled, Clone: 23, BD

Catalog No. BDB611728 Shop All BD Biosciences Products
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BDB611728 50 μg
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Catalog No. BDB611728 Supplier BD Biosciences Supplier No. 611728
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Description

Mouse Monoclonal Antibody

SWI/SNF complexes facilitate gene activation and transcription factor binding byaltering repressive chromatin structures. In mammals, SWI/SNF complexes are present inmutliple forms that include 9-12 proteins called B RG1- a ssociated f actors (BAFs), whichrange in molecular weight from 47 to 250 kDa. BAF60 is the homologue of the yeastSWP70 subunit of the yeast SWI/SNF complex that regulates glucocorticoidtranscription. Three isoforms of BAF60 are BAF60a, BAF60b, and BAF60c. BAF60a isubiquitously expressed and is present in the 200-kDa BRG1 complex. BAF60b andBAF60c are expressed preferentially in muscle and pancreas and may be subunits of adistinct complex that shares some subunits with BRG1 complex. In hematopoietic cells,a SWI/SNF related-complex (PYR) contains BAF57, INI1, BAF60a, and BAF170. This complex binds a 250 bp pyrimidine-rich element between the fetal and adult ß-globingenes and may facilitate human fetal-to-adult globin gene switching. Thus, BAF60proteins are components of multiple SWI/SNF complexes that regulate the transcriptionof various genes.

TRUSTED_SUSTAINABILITY

Specifications

Antigen BAF60a
Applications Western Blot
Classification Monoclonal
Clone 23
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse BAF60a, aa 1-91
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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