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BAFF Receptor Mouse anti-Human, PE, Clone: 11C1, BD

Catalog No. BDB558097 Shop All BD Biosciences Products
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BDB558097 0.1 mg
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Catalog No. BDB558097 Supplier BD Biosciences Supplier No. 558097
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Description

Mouse Monoclonal Antibody

Monoclonal antibody 11C1 reacts with the B cell activating factor receptor (BAFF-R), a type III transmembrane protein of approximately 184 residues. BAFF-R is one of the receptors forB-cell activating factor (BAFF), a member of the TNF family of proteins. BAFF is a key regulator for B cell differentiation and critical in regulating survival and activation of peripheral B cell populations. Experiments in the mouse model show that interaction of BAFF with BAFF-R promotes NF-κB activity. Overexpression of BAFF results in an expanded B cell compartment and autoimmunity in mice. Mice injected with BAFF-neutralizing-Fc (BAFF-R-Fc) protein showed reduced NF-κB activation, blocking BAFF-induced B cell proliferation. Reports suggest that the BAFF-BAFF-R interaction may lead to a better understanding of autoimmune disorders.

TRUSTED_SUSTAINABILITY

Specifications

Antigen BAFF Receptor
Applications Flow Cytometry
Classification Monoclonal
Clone 11C1
Concentration 0.2mg/mL
Conjugate PE
Description BAFF Receptor; BAFF-R; BLyS receptor 3; BR3; TNFRSF13C
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human BAFF-R Transfected Cell Line
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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