BAG4, Rabbit, Monoclonal Antibody, Abnova™

Rabbit monoclonal antibody raised against a human BAG4 peptide using ARM Technology.

Supplier:  Abnova Corporation H00009530K

Catalog No. 89-203-313

Includes: Up to three rabbit IgG clones of 1mg each will be delivered to customer.

Description

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. [provided by RefSeq

Library Construction: Nonfusion antibody library from rabbit spleen (ARM Technology)
Expression: Overexpression vector and transfection into 293H cell line

Order Info

1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.

Specifications

• Antigen: BAG4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: In 1X PBS, pH 7.4
• Gene Accession No.: BAG4
• Gene Symbols: BAG4
• Immunogen: A synthetic peptide of human BAG4
• Regulatory Status: RUO
• Gene ID (Entrez): 9530
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG

• Applications: ELISA, Western Blot
• Concentration: 1mg
• Description: BCL2-associated athanogene 4
• Gene: BAG4
• Gene Alias: BAG-4, SODD
• Host Species: Rabbit
• Quantity: 1 mg x up to 3 Abs
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid