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anti-BCKDHA, Polyclonal, Abnova

Mouse Polyclonal

Manufacturer:  Abnova Corporation H00000593B01

Catalog No. 89-004-967

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

The second major step in the catabolism of the branched-chain amino acids, isoleucine, leucine, and valine, is catalyzed by the branched-chain alpha-keto acid dehydrogenase complex (BCKD; EC 1.2.4.4), an inner-mitochondrial enzyme complex that consists of 3 catalytic components: a heterotetrameric (alpha2, beta2) branched-chain alpha-keto acid decarboxylase (E1), a homo-24-meric dihydrolipoyl transacylase (E2; MIM 248610), and a homodimeric dihydrolipoamide dehydrogenase (E3; MIM 238331). The reaction is irreversible and constitutes the first committed step in BCAA oxidation. The complex also contains 2 regulatory enzymes, a kinase and a phosphorylase. The BCKDHA gene encodes the alpha subunit of E1, and the BCKDHB gene (MIM 248611) encodes the beta subunit of E1.

Detection Antibody, Western Blotting

Specifications

Specifications

branched chain keto acid dehydrogenase E1, alpha polypeptide
Serum
BCKDHA (NP_000700.1, 1 a.a. ∽445 a.a) full-length human protein.
RUO
Primary
Human
Unconjugated
Murine
50μL
Y
Polyclonal
Documents
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