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anti-BCKDHA, Polyclonal, Abnova

Catalog No. 89004967 Shop All Abnova Corporation Products
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Catalog No. Quantity
89-004-967 50 μL
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Catalog No. 89-004-967 Supplier Abnova Corporation Supplier No. H00000593B01

Description

Mouse Polyclonal

The second major step in the catabolism of the branched-chain amino acids, isoleucine, leucine, and valine, is catalyzed by the branched-chain alpha-keto acid dehydrogenase complex (BCKD; EC 1.2.4.4), an inner-mitochondrial enzyme complex that consists of 3 catalytic components: a heterotetrameric (alpha2, beta2) branched-chain alpha-keto acid decarboxylase (E1), a homo-24-meric dihydrolipoyl transacylase (E2; MIM 248610), and a homodimeric dihydrolipoamide dehydrogenase (E3; MIM 238331). The reaction is irreversible and constitutes the first committed step in BCAA oxidation. The complex also contains 2 regulatory enzymes, a kinase and a phosphorylase. The BCKDHA gene encodes the alpha subunit of E1, and the BCKDHB gene (MIM 248611) encodes the beta subunit of E1.

Detection Antibody, Western Blotting

Specifications

Antigen branched chain keto acid dehydrogenase E1, alpha polypeptide
Classification Polyclonal
Conjugate Unconjugated
Host Species Mouse
Immunogen BCKDHA (NP_000700.1, 1 a.a. ∽445 a.a) full-length human protein.
Quantity 50 μL
Regulatory Status RUO
Whole Molecule Yes
Primary or Secondary Primary
Target Species Human
Form Serum
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