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MilliporeSigma™ anti-BDNF Clone: 35928.11,

Catalog No. GF35L100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
GF35L100UG 100 μg Unconjugated
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Catalog No. GF35L100UG Supplier MilliporeSigma™ Supplier No. GF35L100UG

Description

Mouse Monoclonal Antibody

Specifically detects BDNF Clone: 35928.11 in Human samples, and it is validated for ELISA, Immunohistochemistry, Neutralization, Immuno Blotting

Neurotrophic factors define a family of related proteins, which are important in the development, maintenance, and regulation of neurons in both the peripheral and central nervous system. In addition to the prototypical nerve growth factor (NGF), several other factors have been identified which interact with a family of tyrosine kinase receptors. TrkA is the kinase signaling receptor for NGF, while TrkB mediates signaling for both brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5). TrkC is the primary receptor for neurotrophin-3 (NT-3), although this neurotrophin can also activate TrkA and TrkB receptors under certain conditions. Axotomy-induced cell death is one experimental paradigm that has been used to discriminate between the effects of various neurotrophic factors on the survival of different neuronal populations. BDNF, NT-3, and NT-4/5 act as motor neuron survival factors, whereas NGF has no effect on the survival of spinal cord motor neurons. NGF is neuroprotective for cholinergic neurons in the central nervous system. Retrogradely transported NGF-TrkA has also been shown to signal the CREB transcription factor in sympathetic neurons. A putative new member of this gene family, neurotrophin-6 (NT-6), has also been identified from the fish Xephophorus. Like NGF, NT-6 promotes the survival of sympathetic and sensory neurons, albeit with a lower potency.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BDNF
Applications ELISA, Immunoblot, Immunoblot, Immunohistochemistry, Neutralization
Classification Monoclonal
Clone 35928.11
Conjugate Unconjugated
Formulation Lyophilized from PBS, 5% trehalose.
Host Species Mouse
Immunogen recombinant protein consisting of amino acids 129-247 of human BDNF
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽20kDa BDNF protein in brain extracts. Clone 35928.11 was selected based on its ability to neutralize the biological activity of human recombinant BDNF.
Target Species Human
Content And Storage −20°C
Form Purified
Isotype IgG1
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For Research Use Only

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