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beta Tubulin Rabbit anti-Bovine, Canine, Chicken, Feline, Human, Mouse, Non-human primate, Rat, Xenopus laevis, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141331

Catalog No. 01-675-668


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Description

Description

Suggested positive control: antigen standard for TUBB2A (transient overexpression lysate), human brain protein.

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintece. Mutations in the beta tubulin gene are the cause of congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated. The precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression. Ser-172 phosphorylation inhibits tubulin incorporation into microtubules. Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55 kDa subunits: alpha and Beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting.
Specifications

Specifications

beta Tubulin
Polyclonal
Unconjugated
TUBB
Liquid
TUBB, tubb.L, TUBB1
Synthetic peptide corresponding to residues D(417) L V S E Y Q Q Y Q D A T A D E Q G E(435) of human b-Tubulin.
Protein G
RUO
Antibody
Polyclonal
Bovine, Canine, Chicken, Feline, Human, Mouse, Non-human primate, Rat, Xenopus laevis
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 0.05% sodium azide
Q2KJD0, P07437, Q9H4B7, A2AQ07, Q91575
TUBB, TUBB2, dJ40E16.7
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100188929, 101095657, 203068, 380418, 396254, 396427, 474830, 485950, 541271, 545486, 615087, 679312, 81027
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