TGR5 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA523168

Catalog No. PIPA523168

Description

BG37 is a 330 amino acid novel enzyme with seven transmembrane domains. It belongs to the G protein-coupled receptor (GPCR) superfamily and functions as a cell surface receptor for bile acids. Cells expressing BG37 when treated with bile acids induce the production of intracellular cAMP, activate the MAP kinase signaling pathway, leads to the internalization of the receptor and regulates proglucagon gene expression in enteroendocrine cells. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids that can be targeted to improve metabolic control. It is known to be ubiquitously expressed in most of the tissues.

Specifications

• Antigen: TGR5
• Classification: Polyclonal
• Gene: GPBAR1
• Gene Alias: BG37, GPCR19, GPR131, M-BAR, TGR5, G-protein coupled bile acid receptor 1, G-protein coupled bile acid receptor BG37, G-protein coupled receptor GPCR19, hBG37, hGPCR19, membrane bile acid receptor, membrane-type receptor for bile acids
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: Q8TDU6, Q80SS6
• Gene Symbols: GPBAR1
• Immunogen: Synthetic peptide (207 CRDEPSALARALTWRQARAQA 227) of BG37/TGR5 protein.
• Regulatory Status: RUO
• Gene ID (Entrez): 151306, 227289
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid