MilliporeSigma™ anti-BHLHE40/DEC1, Polyclonal

Catalog No.	Quantity	Conjugate
ABN1737MI	100 μL	Unconjugated

Catalog No. ABN1737MI Supplier MilliporeSigma™ Supplier No. ABN1737

Description

Rabbit Polyclonal Antibody

Specifically detects BHLHE40/DEC1 Clone: in Human samples, and it is validated for Western Blotting

Class E basic helix-loop-helix protein 40 (UniProt O14503; also known as Basic helix-loop-helix domain containing class B2, Class B basic helix-loop-helix protein 2, Differentially expressed in chondrocytes 1, Differentially expressed in chondrocytes protein 1, Differentiated embryo chondrocyte expressed gene 1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 protein) is encoded by the BHLHE40 (also known as BHLHB2, DEC1, HLHB2, SHARP2, STRA13) gene (Gene ID 8553) in human. DEC1 (differentially expressed in chondrocytes 1) and DEC2 are E-box-binding transcription factors that exhibit a circadian expression pattern. Both proteins act to repress the Clock/Bmal1-activated E-box promoters via direct E-box binding rather than Bmal1 interaction. In addition, DEC1 is shown to negatively regulate the expression of DEC2. Markedly increased DEC1 expression is observed in colon carcinomas, whereas the opposite trend is seen with DEC2. Likewise cellular DEC1 over-expression results in a proportional decrease in DEC2 level.

Specifications

• Antigen: BHLHE40/DEC1
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
• Gene Accession No.: O14503
• Gene Symbols: BHLHE40, BHLHB2, DEC1, SHARP2, STRA13
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to human BHLHE40/DEC1.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Neuroscience
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_003661
• Target Species: Human
• Content And Storage: −20°C for one year
• Form: Serum

For Research Use Only