MilliporeSigma™ anti-BHLHE40/DEC1, Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABN1737

Catalog No. ABN1737MI

Description

Specifically detects BHLHE40/DEC1 Clone: in Human samples, and it is validated for Western Blotting

Class E basic helix-loop-helix protein 40 (UniProt O14503; also known as Basic helix-loop-helix domain containing class B2, Class B basic helix-loop-helix protein 2, Differentially expressed in chondrocytes 1, Differentially expressed in chondrocytes protein 1, Differentiated embryo chondrocyte expressed gene 1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 protein) is encoded by the BHLHE40 (also known as BHLHB2, DEC1, HLHB2, SHARP2, STRA13) gene (Gene ID 8553) in human. DEC1 (differentially expressed in chondrocytes 1) and DEC2 are E-box-binding transcription factors that exhibit a circadian expression pattern. Both proteins act to repress the Clock/Bmal1-activated E-box promoters via direct E-box binding rather than Bmal1 interaction. In addition, DEC1 is shown to negatively regulate the expression of DEC2. Markedly increased DEC1 expression is observed in colon carcinomas, whereas the opposite trend is seen with DEC2. Likewise cellular DEC1 over-expression results in a proportional decrease in DEC2 level.

Specifications

• Antigen: BHLHE40/DEC1
• Classification: Polyclonal
• Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
• Gene Symbols: BHLHE40, BHLHB2, DEC1, SHARP2, STRA13
• Immunogen: KLH-conjugated linear peptide corresponding to human BHLHE40/DEC1.
• Quantity: 100 μL
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_003661
• Content And Storage: −20°C for one year

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: O14503
• Host Species: Rabbit
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Serum

For Research Use Only