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MilliporeSigma™ anti-BHLHE40/DEC1, Polyclonal
Rabbit Polyclonal Antibody
Supplier: MilliporeSigma™ ABN1737
Description
Specifically detects BHLHE40/DEC1 Clone: in Human samples, and it is validated for Western Blotting
Class E basic helix-loop-helix protein 40 (UniProt O14503; also known as Basic helix-loop-helix domain containing class B2, Class B basic helix-loop-helix protein 2, Differentially expressed in chondrocytes 1, Differentially expressed in chondrocytes protein 1, Differentiated embryo chondrocyte expressed gene 1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 protein) is encoded by the BHLHE40 (also known as BHLHB2, DEC1, HLHB2, SHARP2, STRA13) gene (Gene ID 8553) in human. DEC1 (differentially expressed in chondrocytes 1) and DEC2 are E-box-binding transcription factors that exhibit a circadian expression pattern. Both proteins act to repress the Clock/Bmal1-activated E-box promoters via direct E-box binding rather than Bmal1 interaction. In addition, DEC1 is shown to negatively regulate the expression of DEC2. Markedly increased DEC1 expression is observed in colon carcinomas, whereas the opposite trend is seen with DEC2. Likewise cellular DEC1 over-expression results in a proportional decrease in DEC2 level.
Specifications
BHLHE40/DEC1 | |
Polyclonal | |
Rabbit polyclonal serum with 0.05% sodium azide. | |
BHLHE40, BHLHB2, DEC1, SHARP2, STRA13 | |
KLH-conjugated linear peptide corresponding to human BHLHE40/DEC1. | |
100 μL | |
Neuroscience | |
NP_003661 | |
−20°C for one year |
Western Blot | |
Unconjugated | |
O14503 | |
Rabbit | |
Unpurified | |
RUO | |
Primary | |
Human | |
Serum |
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