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bridging integrator 1, Rabbit, Purified MaxPab™ Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against a full-length human BIN1 protein.
Supplier: Abnova Corporation H00000274D01P
Description
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq
Sequence: MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERVPSpecifications
bridging integrator 1 | |
Polyclonal | |
Rabbit polyclonal antibody raised against a full-length human BIN1 protein. | |
BIN1 | |
AMPH2/AMPHL/DKFZp547F068/MGC10367/SH3P9 | |
Rabbit | |
Affinity Purified | |
RUO | |
Primary | |
Human | |
Antibody |
Immunofluorescence, Western Blot | |
Unconjugated | |
PBS with no preservative; pH 7.4 | |
NM_139348 | |
BIN1 | |
BIN1 (NP_647598.1, 1 a.a. ∼ 482 a.a) full-length human protein. | |
100 μg | |
Cell Cycle | |
274 | |
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
IgG |
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