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Blimp-1 Rat anti-Mouse, Alexa Fluor 647, Clone: 5E7., BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 563643

Catalog No. BDB563643

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The 5E7 monoclonal antibody specifically binds to mouse B lymphocyte-induced maturation protein 1 (Blimp-1). Blimp-1 is a 98 kDa zinc finger-containing protein that is encoded by the Prdm1 gene and functions as a transcriptional repressor. Blimp-1 is essential for regulating the terminal differentiation of activated B cells into plasma cells. In this process, Blimp-1 suppresses genes involved in B cell proliferation, such as Myc and Bcl6. It controls other genes, such as Xbp1, that are required for upregulating the plasma cell’s protein synthesis machinery which is essential for antibody production and secretion. Blimp-1 is an important regulator in other cell types as well. It functions in the regulation of T cell activation and homeostasis and NK cell maturation. Blimp-1 is expressed in activated T cells and can function to inhibit IL-2 production while enhancing the differentiation and expression of several molecules produced by effector T cells.



Alexa Fluor 647
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG2a, κ
Flow Cytometry
Prdm1; PR domain zinc finger protein 1; Blimp1; PRDI-BF1; ZNFPR1A1
Affinity Purified
Mouse Blimp-1 Recombinant Protein
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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