Blimp-1 Rat anti-Mouse, Alexa Fluor 647, Clone: 5E7., BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 563643

Catalog No. BDB563643

Description

The 5E7 monoclonal antibody specifically binds to mouse B lymphocyte-induced maturation protein 1 (Blimp-1). Blimp-1 is a 98 kDa zinc finger-containing protein that is encoded by the Prdm1 gene and functions as a transcriptional repressor. Blimp-1 is essential for regulating the terminal differentiation of activated B cells into plasma cells. In this process, Blimp-1 suppresses genes involved in B cell proliferation, such as Myc and Bcl6. It controls other genes, such as Xbp1, that are required for upregulating the plasma cell’s protein synthesis machinery which is essential for antibody production and secretion. Blimp-1 is an important regulator in other cell types as well. It functions in the regulation of T cell activation and homeostasis and NK cell maturation. Blimp-1 is expressed in activated T cells and can function to inhibit IL-2 production while enhancing the differentiation and expression of several molecules produced by effector T cells.

Specifications

• Antigen: Blimp-1
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: Prdm1; PR domain zinc finger protein 1; Blimp1; PRDI-BF1; ZNFPR1A1
• Immunogen: Mouse Blimp-1 Recombinant Protein
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 5E7.
• Conjugate: Alexa Fluor 647
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Isotype: IgG2a κ