Blimp-1 Rat anti-Mouse, PE, Clone: 5E7, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 564268
The 5E7 monoclonal antibody specifically binds to mouse B lymphocyte-induced maturation protein 1 (Blimp-1). Blimp-1 is a 98 kDa zinc finger-containing protein that is encoded by the Prdm1 gene and functions as a transcriptional repressor. Blimp-1 is essential for regulating the terminal differentiation of activated B cells into plasma cells. In this process, Blimp-1 suppresses genes involved in B cell proliferation, such as Myc and Bcl6 . It controls other genes, such as Xbp1, that are required for upregulating the plasma cell’s protein synthesis machinery which is essential for antibody production and secretion. Blimp-1 is an important regulator in other cell types as well. It functions in the regulation of T cell activation and homeostasis and NK cell maturation. Blimp-1 is expressed in activated T cells and can function to inhibit IL-2 production while enhancing the differentiation and expression of several molecules produced by effector T cells.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Flow Cytometry, Immunocytochemistry|
|Prdm1; PR domain zinc finger protein 1; Blimp1; PRDI-BF1; ZNFPR1A1|
|Mouse Blimp-1 Recombinant Protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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