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BLNK Mouse, Unlabeled, Clone: 2B11, BD

Catalog No. BDB559930 Shop All BD Biosciences Products
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BDB559930 0.1 mg
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Catalog No. BDB559930 Supplier BD Biosciences Supplier No. 559930
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Description

Mouse Monoclonal Antibody

B cell activation is initiated by crosslinking the B cell receptor, which leads to activation of non-receptor protein tyrosine kinases (PTK), including Btk, Syk, and three Src kinases, Fyn, Lyn, and Blk. Activated PTKs then phosphorylate multiple cellular proteins involved in B lymphocyte signaling. Syk is responsible for the tyrosine phosphorylation of B cell l i nk er protein (BLNK), a member of the SLP-76 family of adapter proteins. Phosphorylation of human BLNK at tyrosines 84, 178, and 189 (Y84, Y178, and Y189) creates docking sites for PLC g

The 2B11 monoclonal antibody recognizes BLNK, regardless of phosphorylation status. A fusion protein representing amino acids 4-205 of human BLNK was used as the immunogen. BLNK is expressed as two phosphoproteins migrating at 68 and 70 kDa in SDS/PAGE that represent alternatively spliced forms of human BLNK.

TRUSTED_SUSTAINABILITY

Specifications

Antigen BLNK
Applications Western Blot
Classification Monoclonal
Clone 2B11
Concentration 0.5mg/mL
Conjugate Unconjugated
Description SLP-65, BASH, BCA
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human N-terminal BLNK Recombinant Protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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