BMPR-II Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612292

Catalog No. BDB612292

Description

The transforming growth factor β (TGFβ)/activin/BMP family of growth factor plays a diverse and important role in growth, development, and differentiation. The receptors for this famiy of proteins are type I and II ser/thr kinase receptors. Bone morphogenetic protein receptors (BMPRs) include two type I receptors, BMPR-IA and BMPR-IB, and a type II receptor, BMPR-II. BMPR-II is a widely expressed receptor, with high mRNA expression during development in many tissues. BMPR-II transfected COS-1 cells show binding to BMP-7 (osteogenic protein-1) and BMP-4, and co-transfection with the type I receptor, ActR-I, leads to transcriptional activation in response to BMP-7. In addition, extracellular matrix proteins may regulate the expression of BMPR-II during angiogenesis, since fibrillar type I collagen induces BMPR-II expression in endothelial cells. In familial primary pulmonary hypertension, the BMPR-II gene is mutated in a manner that may disrupt ligand binding, kinase activity, and heteromeric dimer formation. Thus, BMPR-II may be an important mediator of BMP effects during growth and differentiation of endothelial cells.

Specifications

• Antigen: BMPR-II
• Clone: 18
• Conjugate: Unconjugated
• Format: Affinity Purified
• Immunogen: Mouse BMPR-II aa. 803-996
• Quantity: 50μg
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Human, Murine, Rat

• Applications: Western Blot
• Concentration: 250μg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Host Species: Mouse
• Isotype: IgG₁
• Regulatory Status: RUO
• Storage Requirements: Store undiluted at -20°C.
• Monoclonal or Polyclonal: Monoclonal