BMPR2, Mouse, Clone: 2C10, Abnova™

Catalog No.	Quantity
89-016-350	100 μg

Catalog No. 89-016-350 Supplier Abnova Corporation Supplier No. H00000659M02

Description

Mouse monoclonal antibody raised against a partial recombinant BMPR2.

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55kDa and type II receptors of about 70-80kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq

Sequence: NSLDLSATNVLDGSSIQIGESTQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMVSKDIGMNC

Specifications

• Antigen: BMPR2
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 2C10
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant BMPR2.
• Formulation: PBS with no preservative; pH 7.4
• Gene: BMPR2
• Gene Accession No.: NM_001204
• Gene Alias: BMPR-II/BMPR3/BMR2/BRK-3/FLJ41585/FLJ76945/PPH1/T-ALK
• Gene Symbols: BMPR2
• Host Species: Mouse
• Immunogen: BMPR2 (NP_001195.2, 939 a.a. ∼ 1037 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 659
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a κ