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BNC1 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523205

Catalog No. PIPA523205


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Description

Description

Bnc 1 is a 994 amino acid transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. It is a zinc finger protein with three separated pairs of zinc fingers and a nuclear localization signal. Bnc 1 is a soluble protein that can shuttle between the nucleus and the cytoplasm, and its location depends on the proliferative potential of the cell. It is expressed relatively uniformly in the nucleoplasm, and phosphorylation on Ser-537 and Ser-541 leads to its cytoplasmic localization. It is present in the basal cell layer of the epidermis, in hair follicles and also in abundance in the germ cells of testis and ovary, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart. Reports suggest that it plays a regulatory role in keratinocyte proliferation and also in rRNA transcription.  It is also known to play a role in the differentiation of spermatozoa and oocytes.
Specifications

Specifications

BNC1
Polyclonal
Unconjugated
BNC1
Liquid
BNC1
Synthetic peptide (343 VKPERNSLGTKKGR 356) of Bnc 1 protein.
Protein G
RUO
Antibody
Polyclonal
Human, Non-human primate
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q01954
BNC, BSN1, HsT19447, zinc finger protein basonuclin, zinc finger protein basonuclin-1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
646
Documents
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