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BRCA2 Mouse anti-Human, Clone: 234403, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523942

Catalog No. PIMA523942


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Description

Description

This antibody detects endogenous human BRCA2. Reconstitute at 0.5 mg/mL in sterile PBS.

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintece of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Specifications

Specifications

BRCA2
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P51587
BRCA1/BRCA2-containing complex, subunit 2, breast and ovarian cancer susceptibility gene, early onset, breast cancer 2 tumor suppressor, breast cancer susceptibility protein BRCA2, breast cancer type 2 susceptibility protein, fanconi anemia group D1 protein
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
675
Immunohistochemistry, Western Blot
234403
Unconjugated
BRCA2
Lyophilized
BRCA2
E. coli-derived recombit human BRCA2 Met1-Thr200
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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