BRCA2 Mouse anti-Human, Clone: 234403, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523942
This antibody detects endogenous human BRCA2. Reconstitute at 0.5 mg/mL in sterile PBS.Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintece of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
|PBS with 5% trehalose and No Preservative|
|BRCA1/BRCA2-containing complex, subunit 2, breast and ovarian cancer susceptibility gene, early onset, breast cancer 2 tumor suppressor, breast cancer susceptibility protein BRCA2, breast cancer type 2 susceptibility protein, fanconi anemia group D1 protein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry, Western Blot|
|E. coli-derived recombit human BRCA2 Met1-Thr200|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok