breast cancer 2, early onset, Mouse, Clone: 3D12, Abnova™

Catalog No.	Quantity
89-014-063	100 μg

Catalog No. 89-014-063 Supplier Abnova Corporation Supplier No. H00000675M01

Description

Mouse monoclonal antibody raised against a partial recombinant BRCA2.

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq

Sequence: SPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI

Specifications

• Antigen: breast cancer 2, early onset
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 3D12
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant BRCA2.
• Formulation: PBS with no preservative; pH 7.4
• Gene: BRCA2
• Gene Accession No.: NM_000059
• Gene Alias: BRCC2/FACD/FAD/FAD1/FANCB/FANCD/FANCD1
• Gene Symbols: BRCA2
• Host Species: Mouse
• Immunogen: BRCA2 (NP_000050, 3319 a.a. ∼ 3418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 675
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Isotype: IgG3 κ