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MilliporeSigma™ anti-Bst2 Clone: 44E9,

Catalog No. MABF979MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABF979MI 100 μg Unconjugated
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Catalog No. MABF979MI Supplier MilliporeSigma™ Supplier No. MABF979
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Description

Rat Monoclonal Antibody

Specifically detects Bst2 Clone: 44E9 in Human, Mouse samples, and it is validated for Flow Cytometry, Immunocytochemistry, Inhibition Assays, Western Blotting

Bone marrow stromal antigen 2 (UniProt Q8R2Q8; also known as Bst-2, CD317, DAMP-1 protein homolog, HM1.24 antigen, Tetherin) is encoded by the Bst2 (also known as 2310015I10Rik, C87040, GREG) gene (Gene ID 69550) in murine species. Bst-2 is a type II transmembrane glycoprotein that exists as a disulfide bond-linked homodimer on the membrane. In addition, Bst-2 is reported to shuttle between the cell surface and the Golgi apparatus. Bst-2 is expressed in type I IFN-producing cells (IPCs), also known as plasmacytoid dendritic cells (DCs), which function as early responders to viral infections. Bst-2 is also known as tetherin because it prevents the release of enveloped viruses from the host cells by tethering the virions in infected cells. Murine Bst-2 is initially produced with a C-terminal propeptide (a.a. 153-172) sequence, the removal of which yields the mature protein with a large extracellular region (a.a. 52-152), a transmembrane segment (a.a. 31-51), and a short cytoplasmic tail (a.a. 1-30).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bst2
Applications Flow Cytometry, Immunocytochemistry, Inhibition Assays, Western Blot
Classification Monoclonal
Clone 44E9
Conjugate Unconjugated
Formulation Purified rat monoclonal IgG2aκ antibody in PBS without preservatives.
Gene Accession No. Q8R2Q8
Gene Symbols Bst2
Host Species Rat
Immunogen Recombinant protein corresponding to the extracellular domain of mouse Bst2.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation, Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_932763.1
Target Species Human, Mouse
Content And Storage -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Form Purified
Isotype IgG2a κ
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