Btf (Bcl-2 associated Transcription Factor) Mouse anti-Human, Unlabeled, Clone: 5, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611726
Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptotic programs in virus-infected cells regulate viral replication and pathogenesis. However, viruses, such as human adenovirus, have evolved methods of circumventing these programs. The adenovirus E1B encodes a 19kDa protein (E1B 19K) that, similar to Bcl-2, suppresses apoptosis via interactions with intracellular proteins. Btf (Bcl-2 associated Transcription Factor) interacts with E1B 19K, Bcl-2, and Bcl-xL. Two forms of Btf, Btf [L] and Btf [S], differ due to a 49 amino acid deletion in the C-terminal region of Btf [S]. Both forms contain putative basic zipper-like (bZIP) and Myb-like DNA-binding domains. In vitro, Btf binds DNA and represses transcriptional activity. Cotransfection of E1B 19K, Bcl-2, Bcl-xL, and Btf results in the cytoplasmic sequestration of Btf and inhibition of its transcriptional repression activity. Overexpression of Btf induces apoptosis, which is inhibited by E1B 19K. Thus, Btf is an important death-promoting transcriptional factor, which is regulated by anti-apoptotic members of the Bcl-2 family.
Host Species: Mouse
Species Reactivity [for Features Main]: Human
Immunogen: Human Btf [L] aa. 318-439
Immunofluorescence, Western Blotting
|Btf (Bcl-2 associated Transcription Factor)|
|Immunofluorescence, Western Blot|
|Human Btf [L] aa. 318-439|
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