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Btf (Bcl-2 associated Transcription Factor) Mouse anti-Human, Unlabeled, Clone: 5, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611726

Catalog No. BDB611726

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptotic programs in virus-infected cells regulate viral replication and pathogenesis. However, viruses, such as human adenovirus, have evolved methods of circumventing these programs. The adenovirus E1B encodes a 19kDa protein (E1B 19K) that, similar to Bcl-2, suppresses apoptosis via interactions with intracellular proteins. Btf (Bcl-2 associated Transcription Factor) interacts with E1B 19K, Bcl-2, and Bcl-xL. Two forms of Btf, Btf [L] and Btf [S], differ due to a 49 amino acid deletion in the C-terminal region of Btf [S]. Both forms contain putative basic zipper-like (bZIP) and Myb-like DNA-binding domains. In vitro, Btf binds DNA and represses transcriptional activity. Cotransfection of E1B 19K, Bcl-2, Bcl-xL, and Btf results in the cytoplasmic sequestration of Btf and inhibition of its transcriptional repression activity. Overexpression of Btf induces apoptosis, which is inhibited by E1B 19K. Thus, Btf is an important death-promoting transcriptional factor, which is regulated by anti-apoptotic members of the Bcl-2 family.

Host Species: Mouse
Clone: 5
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human Btf [L] aa. 318-439

Immunofluorescence, Western Blotting

Specifications

Specifications

Btf (Bcl-2 associated Transcription Factor)
5
Unconjugated
Murine
IgG1
RUO
Primary
Human
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human Btf [L] aa. 318-439
50μg
Cell Biology
Monoclonal
Documents
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