Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. BDB611726

Btf (Bcl-2 associated Transcription Factor) Mouse anti-Human, Unlabeled, Clone: 5, BD

Catalog No. BDB611726 Shop All BD Biosciences Products
Change view
Click to view available options
Quantity:
50 μg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
BDB611726 50 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. BDB611726 Supplier BD Biosciences Supplier No. 611726

Description

Mouse Monoclonal Antibody

Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptotic programs in virus-infected cells regulate viral replication and pathogenesis. However, viruses, such as human adenovirus, have evolved methods of circumventing these programs. The adenovirus E1B encodes a 19kDa protein (E1B 19K) that, similar to Bcl-2, suppresses apoptosis via interactions with intracellular proteins. Btf (Bcl-2 associated Transcription Factor) interacts with E1B 19K, Bcl-2, and Bcl-xL. Two forms of Btf, Btf [L] and Btf [S], differ due to a 49 amino acid deletion in the C-terminal region of Btf [S]. Both forms contain putative basic zipper-like (bZIP) and Myb-like DNA-binding domains. In vitro, Btf binds DNA and represses transcriptional activity. Cotransfection of E1B 19K, Bcl-2, Bcl-xL, and Btf results in the cytoplasmic sequestration of Btf and inhibition of its transcriptional repression activity. Overexpression of Btf induces apoptosis, which is inhibited by E1B 19K. Thus, Btf is an important death-promoting transcriptional factor, which is regulated by anti-apoptotic members of the Bcl-2 family.

Host Species: Mouse
Clone: 5
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human Btf [L] aa. 318-439

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Btf (Bcl-2 associated Transcription Factor)
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 5
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Human Btf [L] aa. 318-439
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Isotype IgG1
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.