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Btk Mouse anti-Human, Unlabeled, Clone: 53/BTK, BD

Catalog No. BDB611116 Shop All BD Biosciences Products
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Catalog No. BDB611116 Supplier BD Biosciences Supplier No. 611116
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Description

Mouse Monoclonal Antibody

Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling. It is a member of the Tec family of kinases which includes Tec and Itk. In addition to an N-terminal pleckstrin homology (PH) domain, the Tec proteins contain Src homology domains 2 and 3 (SH2 and SH3) and a stretch of 60-80 amino acids between the PH and SH3 domains termed the Tec homology domain. The activity of Btk is regulated by Src-mediated phosphorylation of the kinase domain at tyrosine 551. This event induces Btk kinase activity and subsequent autophosphorylation at tyrosine 223 in the SH3 domain. Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate. The PH domain is essential for proper activation and function of Btk. A mutation in the PH domain results in Xid, murine X-linked immunodeficiency, and human X-linked agammaglobulinemia.

Host Species: Mouse
Clone: 53
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Human N-Terminal Btk aa. 2-172 Recombinant Protein
Formula Weight [Chemical]: 77kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Btk
Applications Western Blot
Classification Monoclonal
Clone 53/BTK
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human N-Terminal Btk aa. 2-172 Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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