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Btk (pY551) & Itk (pY511) Mouse anti-Human, Alexa Fluor 647, Clone: 24A/BTK (Y551), BD

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BDB558134 50 Tests
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Catalog No. BDB558134 Supplier BD Biosciences Supplier No. 558134
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Description

Mouse Monoclonal Antibody

B ruton's t yrosine k inase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling. The activity of Btk is regulated by Src mediated phosphorylation of the kinase domain at tyrosine 551 (Y551). This event induces Btk kinase activity and subsequent autophosphorylation at Y223. Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate. γ1 (PLC γ1), a key regulator of calcium mobilization and extracellular signal-regulated kinase (ERK) activation. Itk is regulated by an activating transphosphorylation event in which Y511 in the kinase domain is phosphorylated by Lck.

The 24a/BTK (Y551) monoclonal antibody recognizes the Y551-phosphorylated form of human Btk and the Y511 phosphorylated form of human Itk.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Btk (pY551) & Itk (pY511)
Applications Flow Cytometry
Classification Monoclonal
Clone 24A/BTK (Y551)
Conjugate Alexa Fluor 647
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human Btk Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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