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Btk (pY551) and Itk (pY511) Mouse, Unlabeled, Clone: 24A/BTK (Y551), BD

Catalog No. BDB558034 Shop All BD Biosciences Products
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Catalog No. BDB558034 Supplier BD Biosciences Supplier No. 558034
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Description

Mouse Monoclonal Antibody

B ruton's t yrosine k inase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling. The activity of Btk is regulated by Src mediated phosphorylation of the kinase domain at tyrosine 551 (Y551). This event induces Btk kinase activity and subsequent autophosphorylation at Y223. Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate. γ1 (PLC γ1), a key regulator of calcium mobilization and extracellular signal-regulated kinase (ERK) activation. Itk is regulated by an activating transphosphorylation event in which Y511 in the kinase domain is phosphorylated by Lck.

The 24a/BTK (Y551) monoclonal antibody recognizes the Y551-phosphorylated form of human Btk and the Y511 phosphorylated form of human Itk.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Btk (pY551) and Itk (pY511)
Applications Western Blot
Classification Monoclonal
Clone 24A/BTK (Y551)
Concentration 0.5mg/mL
Conjugate Unconjugated
Description ATK; BPK; AGMX1
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human Btk Peptide
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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