BTRC Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA535278

Catalog No. PIPA535278

Description

This antibody is predicted to react with mouse based on sequence homology.

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at ′Lys-21′ and ′Lys-22′. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

Specifications

• Antigen: BTRC
• Classification: Polyclonal
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q9Y297
• Gene Symbols: BTRC
• Immunogen: KLH conjugated synthetic peptide between 127-156 amino acids from the N-terminal region of human BRTC1/2
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: BTRC
• Gene Alias: BTRC;BTRCP; FBW1A; FBXW1A; F-box/WD repeat-containing protein 1A; F-box/WD repeat-containing protein 1A; E3RSIkappaB; F-box/WD repeat-containing protein 1A; Epididymis tissue protein Li 2a; F-box/WD repeat-containing protein 1A; F-box and WD repeats prote
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8945
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid