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Bub3 Mouse, Unlabeled, Clone: 31, BD

Mouse Monoclonal Antibody

$260.00

Specifications

Antigen Bub3
Clone 31
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611730
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BD Biosciences
611730
50 μg
Each of 1 for $260.00
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Description

Description

Accurate chromosome segregation requires that all pairs of sister chromatids become appropriately attached to mitotic spindles before the onset of anaphase. Cell cycle checkpoints monitor kinetochore-microtubule interactions, so that cell cycle progression can be delayed until proper chromosome attachments are formed. In yeast, Bub1-3 genes are required for proper mitotic delay in response to unattached kinetochores. In mammals, the homologues to yeast Bub1 and Bub3 form a complex that binds kinetochores and has protein kinase activity. Bub3 contains four WD repeats, three in the N-terminus and one in the C-terminus, and a central Bub1-binding domain. During prophase and prometaphase, Bub3 localizes to the kinetochore before attachment to microtubules. In addition, taxol-induced formation of lagging chromosomes due to a delay of cell cycle progression increases the level of Bub3 co-localized with kinetochores, while correctly aligned chromosomes found in metaphase do not exhibit this co-localization. Thus, Bub3, in association with Bub1, may be important for sensing kinetochore attachment to microtubules during the prometaphase to metaphase transition.

Host Species: Mouse
Clone: 31
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human Bub3 aa. 4-16

Bioimaging, Immunofluorescence, Western Blotting

Specifications

Specifications

Bub3
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
31
Western Blot
Unconjugated
RUO
Human, Mouse, Rat
Human Bub3 aa. 4-16
Primary
Store undiluted at -20°C.
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