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Bub3 Mouse, Unlabeled, Clone: 31, BD

Mouse Monoclonal Antibody

$205.00 - $409.00

Specifications

Antigen Bub3
Isotype IgG1
Immunogen Human Bub3 aa. 4-16
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611730
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BD Biosciences
611730
50μg Each for $205.00
Add to cart
 
BDB611731
View Documents
BD Biosciences
611731
150μg Each for $409.00
Add to cart
 
Description

Description

Accurate chromosome segregation requires that all pairs of sister chromatids become appropriately attached to mitotic spindles before the onset of anaphase. Cell cycle checkpoints monitor kinetochore-microtubule interactions, so that cell cycle progression can be delayed until proper chromosome attachments are formed. In yeast, Bub1-3 genes are required for proper mitotic delay in response to unattached kinetochores. In mammals, the homologues to yeast Bub1 and Bub3 form a complex that binds kinetochores and has protein kinase activity. Bub3 contains four WD repeats, three in the N-terminus and one in the C-terminus, and a central Bub1-binding domain. During prophase and prometaphase, Bub3 localizes to the kinetochore before attachment to microtubules. In addition, taxol-induced formation of lagging chromosomes due to a delay of cell cycle progression increases the level of Bub3 co-localized with kinetochores, while correctly aligned chromosomes found in metaphase do not exhibit this co-localization. Thus, Bub3, in association with Bub1, may be important for sensing kinetochore attachment to microtubules during the prometaphase to metaphase transition.

Host Species: Mouse
Clone: 31
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human Bub3 aa. 4-16

Bioimaging, Immunofluorescence, Western Blotting

Specifications

Specifications

Bub3
Human Bub3 aa. 4-16
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
31
250μg/mL

For Research Use Only.

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