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MilliporeSigma™ anti-c-Abl Clone: 19-110,

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ OP19100UG

Catalog No. OP19100UG

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Specifically detects c-Abl Clone: 19-110 in Human, Mouse samples, and it is validated for Immunoprecipitation, Neutralization

The abl oncogene was initially identified as the viral transforming gene (v-abl) of Abelson murine leukemia virus (A-MuLV), from a chemically thymectomized mouse inoculated with Moloney murine leukemia virus (M-MuLV). The v-abl genome consists of M-MuLV gag sequences fused to mouse c-abl, resulting in the production of gag/c-abl tyrosine kinases, phosphoproteins p160 and p120, as the major translational products. The abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic (CML), 20-25% of adult acute lymphoblastic (ALL) and 2-5% of pediatric ALL. In these leukemias the c-abl proto-oncogene undergoes a chromosomal translocation producing the Philadelphia (Ph1) chromosome resulting in the fusion of c-abl sequences to the bcr gene of chromosome 22. The molecular consequences of this translocation are the generation of a chimeric bcr/c-abl mRNA encoding activated abl protein-tyrosine kinase.
Specifications

Specifications

c-Abl
19-110
In 50mM sodium phosphate buffer, 0.2% gelatin.
Murine
IgG1
RUO
Primary
Recognizes the ∽145kDa human c-Abl, the ∽150kDa mouse c-Abl, v-Abl proteins, and the Bcr/Abl translocation products in ALL (∽190kDa) and CML (∽210kDa). Antibody Target Gene Symbol: ABL1 Target Synonym: ABL, AI325092, bcr/abl, C-ABL, C-ABL 1B, CABL1, E430008G22Rik, JTK7, MGC117749, p145Abl, p150, v-abl Entrez Gene Name: c-abl oncogene 1, receptor tyrosine kinase
Immunoprecipitation, Neutralization
Unconjugated
Purified
a TrpE-v-Abl fusion protein
100μg
2°C to 8°C
Monoclonal
Human, Murine
SDS
Documents
Product Certifications
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