MilliporeSigma™ anti-c-Abl Clone: 24-21,

Catalog No.	Quantity	Conjugate
OP20100UG	100 μg	Unconjugated

Catalog No. OP20100UG Supplier MilliporeSigma™ Supplier No. OP20100UG

Description

Mouse Monoclonal Antibody

Specifically detects c-Abl Clone: 24-21 in Human, Mouse samples, and it is validated for Immunofluorescence, Immunoprecipitation

The abl oncogene was initially identified as the viral transforming gene (v abl) of Abelson murine leukemia virus (A-MuLV), from a chemically thymectomized mouse inoculated with Moloney murine leukemia virus (M MuLV). The v-abl genome consists of M-MuLV gag sequences fused to mouse c-abl, resulting in the production of phosphoproteins, p160 and p120 gag/c-abl with protein-tyrosine kinase activity, as the major translational products. The abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic (CML), 20-25% of adult acute lymphoblastic (ALL), and 2-5% of pediatric ALL. In these leukemias the c-abl proto-oncogene undergoes a chromosomal (9;22) translocation producing the Philadelphia (Ph1) chromosome resulting in the fusion of c-abl sequences to the bcr gene of chromosome 22. The molecular consequences of this translocation is the generation of a chimeric bcr/c-abl mRNA encoding activated abl protein-tyrosine kinase.

Specifications

• Antigen: c-Abl
• Applications: Immunofluorescence, Immunoprecipitation
• Classification: Monoclonal
• Clone: 24-21
• Conjugate: Unconjugated
• Formulation: In 0.05M sodium phosphate buffer, 0.2% gelatin, pH 7.5.
• Host Species: Mouse
• Immunogen: a recombinant protein consisting of the carboxyl region of v-abl protein fused to TrpE
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽145kDa human c-Abl, the ∽150kDa mouse c-Abl, v-Abl, and the Bcr/Abl translocation products in ALL (∽190kDa) and CML (∽210kDa). Does not inhibit protein tyrosine kinase activity. Antibody Target Gene Symbol: ABL1 Target Synonym: ABL, AI325092, bcr/abl, C-ABL, C-ABL 1B, CABL1, E430008G22Rik, JTK7, MGC117749, p145Abl, p150, v-abl Entrez Gene Name: c-abl oncogene 1, receptor tyrosine kinase
• Target Species: Human, Mouse
• Content And Storage: 2°C to 8°C
• Form: Purified
• Isotype: IgG1

For Research Use Only