MilliporeSigma™ anti-c-ErbB2/c-Neu Clone: 3B5,

Catalog No.	Quantity	Conjugate
OP15L100UG	100 μg	Unconjugated

Catalog No. OP15L100UG Supplier MilliporeSigma™ Supplier No. OP15L100UG

Description

Mouse Monoclonal Antibody

Specifically detects c-ErbB2/c-Neu Clone: 3B5 in Human, Mouse samples, and it is validated for Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno Blotting

Amplification of the human proto-oncogene c-neu has been reported to occur in approximately 30% of breast carcinomas and measurement of the amplification has been proposed as a useful predictor of disease prognosis. Gene amplification and the resulting overexpression of proto-oncogene encoded p185^c-neu is thought to transform cells by chronically stimulating signal transduction pathways and in model systems overexpression of human c-neu induces cellular transformation. In the rat model system, a point mutation has been located within the transmembrane domain of the c-neu oncogene. neu (from neuroglioblastomas) is also referred to as erbB-2 (from erythroblastosis virus) and HER2 (for Human Epidermal Growth Factor Receptor) and was the second of four members of the EGF receptor family to be described.

Specifications

• Antigen: c-ErbB2/c-Neu
• Applications: Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
• Classification: Monoclonal
• Clone: 3B5
• Conjugate: Unconjugated
• Formulation: In 0.05M sodium phosphate buffer, 0.2% gelatin.
• Host Species: Mouse
• Immunogen: a synthetic peptide (TAENPEYLGLDVPV) corresponding to amino acids 1242-1255 from the C-terminal domain of human c-ErbB2/c-Neu
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽185kDa c-ErbB2/c-Neu protein in HEK293 cells.
• Target Species: Human, Mouse
• Content And Storage: 2°C to 8°C
• Form: Purified
• Isotype: IgG1

For Research Use Only