MilliporeSigma™ anti-c-ErbB2/c-Neu Clone: 7.16.4,

Catalog No.	Quantity	Conjugate
OP16L100UG	100 μg	Unconjugated

Catalog No. OP16L100UG Supplier MilliporeSigma™ Supplier No. OP16L100UG

Description

Mouse Monoclonal Antibody

Specifically detects c-ErbB2/c-Neu Clone: 7.16.4 in Human, Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Immuno Blotting

Amplification of the human proto-oncogene c-neu occurs in approximately 30% of breast carcinomas and the amplification maybe a useful predictor of disease prognosis. Gene amplification and the resulting overexpression of proto-oncogene encoded proteins is thought to transform cells by chronically stimulating signal transduction pathways and in model systems overexpression of human c-neu induces cellular transformation. In the rat model system, a point mutation has been located within the transmembrane domain of the c-neu oncogene. neu (from neuroglioblastomas) is also referred to as erbB-2 (from erythroblastosis virus) and HER2 (for Human Epidermal Growth Factor Receptor) and was the second of four members of the EGF receptor family to be described.

Specifications

• Antigen: c-ErbB2/c-Neu
• Applications: Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation
• Classification: Monoclonal
• Clone: 7.16.4
• Conjugate: Unconjugated
• Formulation: In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
• Host Species: Mouse
• Immunogen: B104-1-1 cells overexpressing rat c-ErbB2/c-Neu
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽185kDa c-ErbB2/c-Neu protein in overexpressing B104-1-1 cells.
• Target Species: Human, Rat
• Content And Storage: 2°C to 8°C
• Form: Purified
• Isotype: IgG2a

For Research Use Only