MilliporeSigma™ anti-c-ErbB2/c-Neu Clone: 9G6,

Catalog No.	Quantity	Conjugate
OP14L100UG	100 μg	Unconjugated

Catalog No. OP14L100UG Supplier MilliporeSigma™ Supplier No. OP14L100UG

Description

Mouse Monoclonal Antibody

Specifically detects c-ErbB2/c-Neu Clone: 9G6 in Human samples, and it is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation

Amplification of the human proto-oncogene c-neu occurs in approximately 30% of breast carcinomas and the amplification maybe a useful predictor of disease prognosis. Gene amplification and the resulting overexpression of proto-oncogene encoded proteins is thought to transform cells by chronically stimulating signal transduction pathways, and in model systems overexpression of human c-neu induces cellular transformation. In the rat model system, a point mutation has been located within the transmembrane domain of the c-neu oncogene. neu (from neuroglioblastomas) is also referred to as erbB-2 (from erythroblastosis virus) and HER2 (for Human Epidermal growth factor Receptor) and is the second member of the EGF receptor family to be described.

Specifications

• Antigen: c-ErbB2/c-Neu
• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
• Classification: Monoclonal
• Clone: 9G6
• Conjugate: Unconjugated
• Formulation: In 50mM sodium phosphate buffer, 0.2% gelatin.
• Host Species: Mouse
• Immunogen: cells overexpressing human c-ErbB2/c-Neu
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽185kDa c-ErbB2/c-Neu protein in SK-BR-3 cells and breast carcinoma tissue. Does not cross-react with v-ErbB2 or the EGF receptor.
• Target Species: Human
• Content And Storage: 2°C to 8°C
• Form: Purified
• Isotype: IgG1

For Research Use Only