MilliporeSigma™ anti-c-ErbB2/c-Neu Clone: TA-1,

Catalog No.	Quantity	Conjugate
OP39100UG	100 μg	Unconjugated

Catalog No. OP39100UG Supplier MilliporeSigma™ Supplier No. OP39100UG

Description

Mouse Monoclonal Antibody

Specifically detects c-ErbB2/c-Neu Clone: TA-1 in Human samples, and it is validated for Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation, Immuno Blotting

Amplification of the human proto-oncogene c-neu occurs in approximately 30% of breast carcinomas and the amplification maybe a useful predictor of disease prognosis. Gene amplification and the resulting overexpression of proto-oncogene encoded proteins is thought to transform cells by chronically stimulating signal transduction pathways and in model systems overexpression of human c-neu induces cellular transformation. In the rat model system, a point mutation has been located within the transmembrane domain of the c-neu oncogene.

Specifications

• Antigen: c-ErbB2/c-Neu
• Applications: Flow Cytometry, Immunoblot, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation
• Classification: Monoclonal
• Clone: TA-1
• Conjugate: Unconjugated
• Formulation: In 50mM PBS, 0.2% gelatin, pH 7.5.
• Host Species: Mouse
• Immunogen: cells overexpressing human c-ErbB2/c-Neu
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽185kDa c-ErbB2/c-Neu protein in SK-BR-3 cells.
• Target Species: Human
• Content And Storage: 2°C to 8°C
• Form: Purified
• Isotype: IgG1

For Research Use Only