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MilliporeSigma™ anti-c-ErbB3 Clone: H3.90.6 or Ab90,

Catalog No. OP119100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
OP119100UG 100 μg Unconjugated
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Catalog No. OP119100UG Supplier MilliporeSigma™ Supplier No. OP119100UG
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Description

Mouse Monoclonal Antibody

Specifically detects c-ErbB3 Clone: H3.90.6 or Ab90 in Human samples, and it is validated for Flow Cytometry, Immunofluorescence, Immunoprecipitation

ErbB3/HER3, a member of the epidermal growth factor receptor (EGF-R) family, was originally isolated as a cDNA clone from a human carcinoma cell line. The molecule is transcribed from a 6-kilobase mRNA, which can be identified in a variety of different tissues. Epidermal growth factor (EGF) initiates its effects on cell growth through interaction with a 170,000 dalton cell surface glycoprotein receptor. Binding of EGF, amphiregulin, or transforming growth factor-alpha (TGF-α) to the receptor or to other members of the receptor family activates a tyrosine-specific protein kinase intrinsic to the EGF-receptor protein family. While there is a large degree of conserved homology between the cytoplasmic regions of EGF-R and HER2/neu, the HER3 molecule is more unique. This observation suggests that HER3 is subject to regulatory signals distinct from those affecting EGF-R and HER2/neu and, therefore, signals an alternate biochemical response. In particular, it has been shown that the ligand for HER3 is NDF/heregulin a property shared with HER4. c-ErbB3/HER3 is overexpressed in a variety of tumors (e.g., breast, stomach, pancreas and colon).
TRUSTED_SUSTAINABILITY

Specifications

Antigen c-ErbB3
Applications Flow Cytometry, Immunofluorescence, Immunoprecipitation
Classification Monoclonal
Clone H3.90.6 or Ab90
Conjugate Unconjugated
Formulation In 10mM PBS, pH 7.4.
Host Species Mouse
Immunogen recombinant, human ErbB3 extracellular domain
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽185kDa c-ErbB3/HER3 protein in T47D cells and breast carcinoma tissue.
Target Species Human
Content And Storage −20°C
Form Purified
Isotype IgG2a
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For Research Use Only

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