MilliporeSigma™ anti-c-ErbB3 Clone: H3.90.6 or Ab90,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma™ OP119100UG
Specifically detects c-ErbB3 Clone: H3.90.6 or Ab90 in Human samples, and it is validated for Flow Cytometry, Immunofluorescence, ImmunoprecipitationErbB3/HER3, a member of the epidermal growth factor receptor (EGF-R) family, was originally isolated as a cDNA clone from a human carcinoma cell line. The molecule is transcribed from a 6-kilobase mRNA, which can be identified in a variety of different tissues. Epidermal growth factor (EGF) initiates its effects on cell growth through interaction with a 170,000 dalton cell surface glycoprotein receptor. Binding of EGF, amphiregulin, or transforming growth factor-alpha (TGF-α) to the receptor or to other members of the receptor family activates a tyrosine-specific protein kinase intrinsic to the EGF-receptor protein family. While there is a large degree of conserved homology between the cytoplasmic regions of EGF-R and HER2/neu, the HER3 molecule is more unique. This observation suggests that HER3 is subject to regulatory signals distinct from those affecting EGF-R and HER2/neu and, therefore, signals an alternate biochemical response. In particular, it has been shown that the ligand for HER3 is NDF/heregulin a property shared with HER4. c-ErbB3/HER3 is overexpressed in a variety of tumors (e.g., breast, stomach, pancreas and colon).
|H3.90.6 or Ab90|
|In 10mM PBS, pH 7.4.|
|Recognizes the ∽185kDa c-ErbB3/HER3 protein in T47D cells and breast carcinoma tissue.|
|Flow Cytometry, Immunofluorescence, Immunoprecipitation|
|recombinant, human ErbB3 extracellular domain|
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